Heat the broiler with the rack in the center position. On rimmed a baking sheet, combine the panko breadcrumbs, 1 tbsp olive oil, 1/2 tsp salt, oregano, and garlic powder and toss to combine. Spread in an even layer and broil until golden, about 2-3 minutes. (Watch closely, it can burn quickly!) Remove the panko from the oven and set aside. Keep the broiler on.
On separate rimmed baking sheet, pour 1 tbsp of olive oil over the tilapia filets, and use your hands to coat the surface of the fish completely. Season with ½ tsp salt, cayenne, and chili powder. Broil 8-12 minutes, or until fish is opaque throughout. (Your filets may pop and hiss a bit toward the end of cooking, but that is normal!)
Remove the fish from the oven and transfer to a cutting board. Cut the fish into bite-sized pieces, and serve with the avocado, red cabbage, onion, lime, jalapeno, cilantro, sour cream, hot sauce, tortillas, and prepared panko.